Participaron 81 pacientes con AR temprana, 81 pacientes con AR establecida, 58 pacientes con otras enfermedades reumáticas e inflamatorias y 43 individuos sanos. Se sintetizó un péptido del fibrinógeno citrulinado diseñado por predicción informática y se utilizó en un inmunoanálisis enzimático.
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The immunoassay designed with a citrullinated fibrinogen peptide has a high diagnostic value and can identify patients with greater clinical activity in early rheumatoid arthritis.ĭeterminar el valor diagnóstico de los anticuerpos contra un péptido del fibrinógeno citrulinado, en pacientes cubanos con artritis reumatoide (AR), mediante un inmunoanálisis enzimático. The positivity of C-reactive protein was associated with the presence of anti-citrullinated fibrinogen peptide antibodies and the titres of these antibodies correlated with clinical activity in early disease. Specificity (89%) and positive predictive value (88%) were higher than rheumatoid factor, similar to anti-mutated citrullinated vimentin, but lower than second generation anti-citrullinated peptides assay. Resultsĭetermination of anti-citrullinated peptide of fibrinogen antibodies by the designed enzyme immunoassay showed the best diagnostic value in early rheumatoid arthritis patients, with the highest value sensitivity (84%), negative predictive value (85%), Youden index (0.73%) and area under the receiver operating curve (0.9192). Anti-citrullinated fibrinogen peptide, anti-mutated citrullinated vimentin, anti second generation citrullinated peptides and rheumatoid factor antibodies were determined by enzyme-linked immunosorbent assay. The participants were 81 patients with early disease, 81 patients with established disease, 58 patients with other rheumatic and inflammatory diseases, and 43 healthy individuals. Materials and methodsĪ citrullinated peptide of fibrinogen designed by informatics prediction was synthesised and used in an enzyme immunoassay. To determinate the diagnostic value of an antibody against a citrullinated fibrinogen peptide in Cuban patients with rheumatoid arthritis, using an enzyme immunoassay.